In an ischemic stroke model, exendin-4 enhanced the activation of PI3K/Akt/CREB signaling, leading to upregulation of APE1, a key enzyme responsible for resolving oxidized bases and single-strand breaks, which reduced nuclear DNA fragmentation and preserved neuronal viability (75, 76)
[DOI] [PubMed] [Google Scholar] Patterson JT, Day JW, Gelfanov VM, DiMarchi RD
When Hh signalling was suppressed by smo-RNAi , the dpp transcription level was mildly reduced compared with that in wild type (Fig
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