In Alzheimer's Disease, 6-Month Treatment with GLP-1 Analog Prevents Decline of Brain Glucose Metabolism: Randomized, Placebo-Controlled, Double-Blind Clinical Trial
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This therapeutic strategy-combining GLP-1 and estrogen receptor activationwas developed to enhance metabolic benefits while limiting systemic estrogen exposure, thereby minimizing reproductive and oncogenic risks
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GLP-1R is found in many organs like pancreas, kidney, GI tract and brain, but is highly expressed in pancreas