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RIPA buffer was used to obtain mouse pancreatic tissue lysates

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The researchers assessed the change in body weight from baseline within each trial and subgroup and they also carried out a mediation analysis to differentiate between direct and indirect effects of semaglutide on weight loss, the latter of which was mediated by nausea or vomiting

Adv Sci (Weinh) (2023) doi: 10.1002/ADVS.202204514

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