Key Nutrients to Monitor Vitamin B12 GLP-1 drugs can slow gastric emptying, which might affect the absorption of vitamin B12, particularly in individuals with pre-existing deficiencies or those on long-term therapy
SGLT2 Inhibitors No pharmacokinetic interaction studies have identified clinically meaningful changes when empagliflozin, dapagliflozin, or canagliflozin are combined with GLP-1 RAs
These risks are still being investigated but research suggests these drugs reduce gallbladder motility (emptying), alter the composition of bile (due to rapid weight loss), and lead to biliary stasis (bile sitting too long)all of which can contribute to gallstones and inflammation
4648 Mechanistically, TMAO may induce T2DM by inducing pancreatic -cell dysfunction, chronic inflammation, oxidative stress, and disrupting glucose and lipid homeostasis
To administer 5mg (5000mcg): you would draw 250 units (2.5ml) on a U-100 insulin syringe
Weight regain depends on whether you maintain the nutrition and activity habits you developed during semaglutide therapy