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10.1016/j.freeradbiomed.2008.03.011 [DOI] [PMC free article] [PubMed] [Google Scholar] Lewis CA, Parker SJ, Fiske BP, McCloskey D, Gui DY, Green CR, Vokes NI, Feist AM, Vander Heiden MG, Metallo CM

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The overall conformational flexibility of the ectodomain is also reduced by the constraints imposed by the disulfide-linked CT elements that cross-link the two scLCDV1-VILP-bound L1-CR modules, resulting in the ectodomains points of membrane entry and the associated intracellular domains becoming further separated, rather than closer together as they do when IGF-1 binds