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Exenatide IR (immediate-release) is given twice daily, while exenatide ER is a once-weekly microsphere formulation

A telehealth program like Willow may help with reminders and access, but it can't fully overcome issues like cost, side effects, or ambivalence about lifestyle change

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However, there is ongoing debate regarding their efficacy, as some studies suggest that oral forms may not be fully absorbed by the body

Starting a probiotic before or simultaneously with retatrutide initiation may help maintain microbiome stability during the adjustment period

These include blood concentrations of total cobalamin, holo-transcobalamin (vitamin B 12 bound to transcobalamin, one of the two carrier proteins in blood