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Not because of microbial contamination (bacteriostatic water prevents that), but because oxidative degradation accelerates logarithmically after the 4-week mark

Do not apply ZORBIUM if the application site at the dorsal cervical area has diseased or injured skin, or to anatomic areas other than the dorsal cervical area because absorption characteristics may be different

It performs many essential functions in the body

For sensitive skin or chronic conditions, start with low concentration, patch-test behind the ear or inner arm, then apply to the face if no reaction occurs

And they started working out how it might be doing all this

Eating a diet high in antioxidants and low in sugar may provide similar benefits as taking extra supplements