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Given the long safety record of these drugs, the low microdoses some people take carry minimal risk, even if the cognition-specific trials have not been done

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Bioorg Chem 32 , 234243, (2004)

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This may lead to lipotoxicity via activation of inflammatory pathways and production of inflammatory adipocytokines such as TNF-, plasminogen activator inhibitor 1, retinol-binding protein 4, and resistin which disrupt glucose disposal [12, 13]