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A.PunthakeeZ.et al (2011)

If you know or suspect that your pen has been exposed to freezing temperatures, temperatures above 30C, or has been out of the refrigerator for more than 28 days, you should discard it even if it appears normal

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GLP-1 receptors are abundant in the gastrointestinal tract, and semaglutide's activation of these receptors alters gut motility and the overall digestive process

This dual action (enhanced insulin secretion plus delayed gastric transit) explains why semaglutide typically lowers fasting glucose first, then progressively reduces postprandial (after-meal) glucose spikes over 24 weeks