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LIMITATION The sample size in our study was small

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The ORR was 58% (7/12) after 6 cycles of RG7388 monotherapy

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The thermal cycling comprised an initial denaturation step at 95 C for 4 min, followed by 35 cycles at 95 C for 30 s, 59 C for 30 s and 72 C for 30 s, with the final extension at 72 C for 7 min