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These agents bind to GLP-1 receptors in tissues critical for glucose regulation, including pancreatic -cells (29)

injection, note that while injections are proven, "is oral tirzepatide effective" remains uncertain without proper testing

Blood glucose levels in patients with prediabetes or insulin resistance may gradually rise as the glucose-lowering effects of tirzepatide wane

Your doctor will weigh BMI alongside waist circumference, abdominal fat distribution and metabolic risk factors

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*Lancet Diabetes Endocrinol.* 2021;9(12):776-785