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That last claim sounds extraordinary

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PhAN9 (A12M): PhAN9 _A12M_fw, PhAN9 _A12M_rv, PhAN9 (C13S): PhAN9 _C13S_fw, PhAN9 _C13S_rv, PhAN9 (N108H): PhAN9 _N108H_fw, PhAN9 _N108H_rv (Supplementary Table 4) using pANT15 as template

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This severe glutamine deprivation leads to dramatic histone hypermethylation due to decreased -KG levels subsequent to decreased activity of Jumonji domain-containing histone demethylases and results in cancer cell dedifferentiation and resistance to BRAF inhibitors 103

The combination is a community-derived protocol structure