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The PKC family is composed of various serine/threonine kinase subtypes

it's released in massive pulses, primarily during deep sleep and after intense exercise

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EBioMedicine 118 , 105836 (2025)

In terms of frequency, short-term high-frequency administration (e.g., once daily for 3 consecutive days) enables rapid initiation of therapeutic efficacy, whereas long-term administration once weekly or once every 2 weeks is sufficient to maintain stable improvements, which aligns with clinical practice requirements (Klinger et al., 2021)