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While vitamin B6 is generally regarded as a safe and essential nutrient, excessive intake, especially doses exceeding 200 mg per day over several months, can lead to sensory neuropathy

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By inducing apoptosis and halting the cell cycle, these two classes of compounds effectively inhibit the proliferation and growth of tumor cells

By encapsulating the payload, prolonging systemic circulation, and incorporating surface functionalization (e.g., with targeting ligands), these systems dramatically enhance the tumor-specific accumulation and intracellular delivery efficiency of nucleic acid drugs [250, 251], This advanced delivery capability makes it feasible to precisely switch off resistance genes at the transcriptional or translational level, a principle convincingly demonstrated by studies in which functionalized nanoparticles successfully reversed tumor drug resistance through targeted gene silencing [252, 253]

CDKN2A mutations with p14 loss predisposing to multiple nerve sheath tumours, melanoma, dysplastic naevi and internal malignancies: a case series and review of the literature