Borg CM, le Roux CW, Ghatei MA, Bloom SR, Patel AG, Aylwin SJ
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Gastrointestinal effects predominate: | Side Effect | Orforglipron | Oral Semaglutide | Tirzepatide | |-------------|-------------|-----------------|-------------| | **Nausea** | 22-28% | 24-28% | 24-31% | | **Vomiting** | 8-12% | 10-14% | 9-13% | | **Diarrhea** | 14-18% | 12-16% | 14-21% | | **Constipation** | 10-14% | 8-12% | 11-15% | | **Dyspepsia** | 6-9% | 8-11% | 5-8% | | **Discontinuation due to AEs** | ~6-8% | ~7-9% | ~4-7% | A notable difference: oral semaglutide has higher rates of upper GI symptoms (reflux, dyspepsia) because the SNAC formulation makes direct contact with gastric mucosa
Research protocols have used similar formulations to investigate fat transport mechanisms, hepatic lipid clearance, and one-carbon metabolism
doi: 10.1104/pp.106.07707
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