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Its currently in the experimental phase but has shown impressive results in clinical trials

However, a systematic, mechanism-based understanding of how its natural products combat renal fibrosis is conspicuously absent

In clinical trials of once-daily or BID GLP-1 receptor agonists (liraglutide, lixisenatide, or exenatide BID), mean changes in body weight were 2.1 to 2.9 kg for monotherapy and +0.3 to 3.6 kg in combination with oral antihyperglycemic therapies (13,14,18)

The clinical significance extends beyond blood test numbers to actual disease progression prevention

Enhancing endogenous NO production should provide physiological and more sustained effects

D., Schaefer, J