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Several mechanisms may potentially contribute to blood pressure effects, including: weight loss (a well-established factor in blood pressure reduction), possible promotion of natriuresis (sodium excretion by the kidneys), and theoretical improvements in endothelial functionthough many of these mechanisms remain hypothetical rather than definitively proven

334,569 The increased NADH/NAD + ratio and protein hyperacetylation are found in the HF patients hearts and pathologically hypertrophied mice

10.1073/pnas.58.2.719 567 StuchfieldD.BarranP

Causes vasodilation

Possible side effects may still include: These effects are typically temporary and improve as your body adjusts

Seal, 2000