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However, in another intervention trial with combination therapy (53), the risk of adverse effects was significantly higher in the Se supplementation group, which we speculate may be related to unclear baseline Se levels in the subjects and a narrower safety window during Se treatment

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Anticipated delivery at University Hospital of Nantes was among inclusion criteria to ensure adequate blood sample collection

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Second-messenger and pathway readouts: Experimental models may assess pathway outputs (assay-dependent) to profile signaling behavior and compare conditions

10.1021/acs.chemrev.0c00576 31 KilariD.GuancialE.KimE