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275,276 Monosodium urate crystals are ingested by monocytes via phagocytosis, engaging Toll-like receptors (TLRs) such as TLR2 and TLR4

Asplin CM, Faria AC, Carlsen EC, Vaccaro VA, Barr RE, Iranmanesh A, Lee MM, Veldhuis JD, Evans WS

Several NAD+ precursor molecules were released to replace NAD+, demonstrating that NAD+ replacement is what generates the beneficial effects (25)

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