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This is not well understood mechanistically but may relate to individual sensitivity, dehydration, or unrelated factors coinciding with supplement use

HGH at higher doses is associated with joint pain, significant fluid retention, insulin resistance, and potential organ enlargement with chronic supraphysiological exposure

There are two factors to consider, however

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These events lead to a state of vascular inflammation, which may be partially mediated by ROS formed by activated mononuclear cells