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Studies have shown that bitter-tasting pharmaceuticals and substances, including polyphenols such as isosinensetin, bind to bitter taste receptors, and unlike other TAS2R agonists, stimulate GLP-1 secretion in NCI-H716 cells [192] (Fig
Sim R et al
A balanced diet rich in magnesium (leafy greens, nuts, whole grains), potassium (bananas, potatoes, beans), and calcium (dairy products, fortified alternatives) can help maintain electrolyte balance
Conversely, for DDES, some comparative evidence suggests that SGLT2 inhibitors may offer a greater risk reduction than GLP-1RAs [127]
N Engl J Med (2017) 377(13):122839