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This cascade restores PINK1/Parkin-dependent mitophagy and concurrently activates the NRF2 pathway, enhancing antioxidant responses, like NQO-1and HO-1, and consequently reducing oxidative stress in ectopic lesions

Consequently, despite the clear message of landmark trials such as the Diabetes Control and Complications Trial and the UK Prospective Diabetes Study regarding the need for excellent glycemic control, diabetes remains the leading cause of blindness, renal failure, and amputations

PMID: 12937682

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Diagnostic methods based on metabolic reprogramming in CRC The metabolic reprogramming in CRC creates diagnostic opportunities by exploiting cancer-specific metabolic alterations

Prucalopride in Gastroparesis: a Randomized Placebo-Controlled Crossover Study