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In practice, potential benefits are not universal: it depends on the context (diet, nutritional status, training level or medical conditions)

- Out of pocket cost paid by members is typically based on the drugs list price (before discounts and rebates) unless rebates are passed through to members up front, which is uncommon

Expect irregular cycles during rapid weight loss phase, typically heavier or lighter flow, cycle length changes of 3-7 days, or temporary absence of periods if losing weight very quickly