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GHK-Cu is administered as a daily subcutaneous injection with a 30-day cycle followed by a 30-day break

A subcutaneous (SC) injection takes a slightly different approach

FIGURE 2 The accumulation of methylmalonic acid (MMA) and Hcy because of these disruptions leads to oxidative damage and impaired methylation

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This is the route used in every animal study demonstrating GHK-Cu's effects beyond the skin

studied 69 patients with IC/PBS (diagnosed based on the 1987 NIH criteria and including both ESSIC types 2 and 3) and 37 controls (with and without non-IC/BPS chronic cystitis) and demonstrated that the presence of mast cells correlated with the level of background lymphoplasmacytic infiltrate, but not with the diagnosis of IC