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Specialized testing for tirzepatide levels is not performed in routine clinical practice

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What GIP Receptor Agonism Adds The GIP receptor (GIPR) is expressed in pancreatic -cells (similar to GLP-1R), adipose tissue, bone, brain, and cardiovascular tissue

Controlled dosing is important for long-term use

In addition, intestinal epithelial cells (IECs), otherwise known as enterocytes, are adjoined by TJ complexes that are further tethered to an intracellular cytoskeleton permitting communication across the epithelium and regulating processes including the cell cycle (Brenchley and Douek 2012)

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