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Treatment recommendations are individualized and based on safety, appropriateness, and clinical judgment

doi: 10.1016/j.molmet.2020.101102 23 AstrupACarraroRFinerNHarperAKunesovaMLeanMEJet al

GLP-1 receptor agonists such as semaglutide have demonstrated robust efficacy in obesity research, while dual GLP-1/GIP agonists like tirzepatide have pushed those results further

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The researchers also observed that 532 participants with BMI 35 at week 0, who had tolerated their assigned dose of medication, were then escalated to the maximum tolerated dose (9mg or 12mg) for a further 24 weeks