Phase 3 clinical trials are an important step to prove a drugs efficacy and safety before the FDA grants regulatory approval to new treatments or uses of existing medications, and the company that makes semaglutide now plans to seek approval this year following these recent studies
The obesity rate in adolescents has quadrupled over the last 30 years
The patient was referred to endocrinology for evaluation of insulin resistance where he was started on tirzepatide monotherapy, 2.5 mg every 7 days
Of note, the finding of a markedly greater benefit on HF of efpeglenatide amongst trial participants using SGLT2 inhibitors at enrolment in the AMPLITUDE-O CVOT highlights another important point (Lam et al., 2021)
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Every new weight loss medication gets called "revolutionary" before the data comes in, and most fall short