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The relatively stable size of the overall lesion can be explained by the fact that their slow rate of proliferation is offset by cell-attritional factors such as immunosurveillance

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The clinician should look for and map out the locations of Hunner lesions during the early phase of cystoscopy since the lesions may begin to bleed during bladder filling and may be obscured later

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These changes in membrane proteins and lipids contribute to functional and structural alterations that decrease erythrocyte membrane stability and deformability and trigger premature RBC removal [12, 24]