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A significant down-regulation of several other enzymes related to energy metabolism was also confirmed at the protein level in riboflavin deficient cells, such as DLD, SDHA, NDUFS1, and NDUFV2

Foraker AB, Khantwal CM, Swaan PW

This activation also occurs in extra-renal tissues, such as the ovary and adipose tissue, which express these enzymes, enabling local calcitriol production and establishing tissue-specific responses (81, 82)

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