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2022 The major difference between these agents lies in canagliflozin, which is less selective for SGLT2 over SGLT1 and is metabolized primarily in the liver (compared to kidneys), and sotagliflozin, which inhibits both SGLT1 and SGLT2

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In: NormanAWSchaeferKGrigoleitHGetal., editors

In contrast, eryptosis inducers have previously been tested in vitro in the absence of human serum or a synthetic replacement ( Figure 3 )