It is believed however that Contrave works on two sections of the brain, the mesolimbic reward system which helps to control cravings and the hypothalamus that helps to reduce levels of hunger
Genome Biology
Screening may be warranted in patients with one or more risk factors, such as gastric or small intestine resections, inflammatory bowel disease, use of metformin for more than four months, use of proton pump inhibitors or histamine H 2 blockers for more than 12 months, vegans or strict vegetarians, and adults older than 75 years
Efficacy of glucagon-like peptide-1 and estrogen dual agonist in pancreatic islets protection and pre-clinical models of insulin-deficient diabetes
But, as we've said, the mechanism is only part of the story
Mechanism of action of GLP-1 receptor agonists: Direct receptor binding These medications bind specifically to GLP-1 receptors on pancreatic beta cells, stimulating insulin secretion in a glucose-dependent manner (meaning they work when blood glucose is elevated)