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As IGF-1R mAbs are already in clinical trials, these observations warrant further exploration into the possible development of these drugs for safe and effective long-term use in humans as a strategy to delay at least some manifestations of aging

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One final convergence point of these related signaling events, is the initiation of the p38 MAPK and MAPK/ERK1/2 signaling pathways, that causes changes in gene expression and can modify cell metabolism and proliferation (47)

(14) It is hypothesized that GHK-Cu may influence various biochemical pathways and molecular markers related to inflammation and oxidative stress, although the specific mechanisms remain somewhat uncertain

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