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doi: 10.1016/j.ssmph.2021.100731 36

NAC is a supplemental form of cysteine

Marked interindividual heterogeneity exists in platinum accumulation and toxicity severity among patients with similar cumulative doses, which is mainly mediated by genetic polymorphisms (e.g., GSTP1), epigenetic modifications, and baseline health status

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In mitochondria, SIRT4 regulates energy metabolism, such as regulating the TCA cycle by downregulating the activity of GDH and malonyl coenzyme A decarboxylase (MCD)

Furthermore, the complex interplay of immune cells, endothelial responses, and microbial metabolites in vivo is difficult to fully capture in experimental models (Limbad et al., 2024)