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Semaglutide benefits all HbA1c groups Of the study participants, 33.5% had normoglycemia at baseline, 34.6% had low-range prediabetes, and 31.9% had high-range prediabetes

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Over time, this energy shortfall sets off a cascade of downstream effects: synaptic dysfunction, impaired protein clearance, neuroinflammation, and ultimately the accumulation of amyloid- and tau pathology Importantly, imaging and metabolic studies consistently show that reductions in cerebral glucose metabolism and perfusion precede cognitive symptoms by years, often decades [8]

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