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Thymosin beta-4, connective-tissue organisation and rat wound repair

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doi: 10.1371/journal.pone.0214412

The two work through different mechanisms and may produce additive benefits

No completed, published Phase II human trial exists for either route as of mid-2025

This creates an ecological vacuum in the microbiome, allowing opportunistic pathogens and pro-inflammatory Gram-negative bacteria, such as Streptococcus and certain Clostridium species, to proliferate unchecked