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However, CJC-1295 (especially the DAC version) can cause sustained elevation in IGF-1, whichif mismanagedmay increase the risk of: Insulin resistance Carpal tunnel syndrome Soft tissue growth (in rare, prolonged cases) Pituitary overstimulation That said, these issues are more often associated with excessive dosing or continuous high-frequency use

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They also saw kidney dysfunction due to age reversed as kidneys grew more healthy (with the senescent cells killed off, healthy cells could flourish)

The FDA has approved a number of peptide drugs for various medical applications

JH and XF consulted literatures and wrote the manuscript in equal contribution