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For example, the brain derived neurotrophic factor (BDNF), a neurotrophin highly expressed in the hypothalamus and other brain centers involved in homeostatic regulation of energy balance, seems to ameliorate the diabetic and obese phenotype of LepR deficient mice [52,53,54]

This may be due to the significant differences in gut microbial diversity between humans and animals (Peng et al., 2013)

Besides, intestine-derived HDL 3 has a unique role in the prevention of liver damage from gut-derived LPS, implying that HDL 3 might be a target for treating liver illness linked with gut leakiness

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