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18 Although treatments are available for diabetes and obesity, there are multiple long-term complications: they remain the leading causes of cardiovascular disease, eye pathology, lower limb amputation and end-stage renal disease

In addition, a large proportion of the GLP-1 RA group (13.8%) had received DPP-4is before baseline, whereas only 0.8% of the DPP-4i group had received GLP-1 RAs prior

Think of these receptors as the locks, and your GLP-1 hormone is the key

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doi:10.1001/jama.2021.1831 10.A Research Study to See How Semaglutide Helps People With Excess Weight, Lose Weight (STEP UP) (STEP UP)

Some pharmacokinetic studies have examined the lower end of the dose-response curve, but these were conducted to establish appropriate starting doses for titration, not to validate microdosing as a standalone strategy