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[116], the increased production of superoxide radicals (O 2 ) resulting from T2D hyperglycemia can rapidly react with nitric oxide (NO) to produce peroxynitrite (ONOO ), which can subsequently react with protein (and apolipoprotein) tyrosine residues to form 3-nitro-tyrosine (3-NT)

E.et al (2023)

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FDAs Q2(R2) guidance identifies analytical validation concepts such as specificity, accuracy, precision, and range, which belong to method and data review rather than calculator interpretation [2]

HGP is decreased in Dpp4 hep/ mice but not mice with deletion of Dpp4 from Tie2 + endothelial cells via GLP-1 and GIP-dependent pathways