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12.1 Future prospects Countless ATs have been synthesized to date, and many more will undoubtedly follow

Contributing factors include reduced GHRH (stimulating hormone) secretion, increased somatostatin (inhibiting hormone) tone, changes in sleep architecture (less deep sleep), increased body fat (which suppresses GH), and decreased receptor sensitivity

These compounds are not approved for human or veterinary use unless specifically noted in an approved drug context, such as tesamorelin for HIV-associated lipodystrophy

This phenotype was explored in both mouse models and in vitro with an anti-IL-23 antibody to block IL-23 signaling where mice experienced prolonged survival and decreased tumor burden, and CD8 + cells in mice and in vitro showed enhanced cytotoxicity in the IL-23-depleted state [154] (Fig