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A recent study introduces a peptide PROTAC specifically designed to target and degrade the cysteine-histidine-rich 1 (CH1) domain of p300, a vital co-activator involved in oncogenic signaling pathways, particularly in PCa (Zhang et al., 2024)

This property could be particularly beneficial for those with osteoarthritis, where cartilage degradation is a key issue

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However, several earlier studies using conventional (non-nanoformulated) GTE in boar semen cryo-extenders found no improvements in motility, viability, acrosome integrity, or membrane function 35 , and others reported no toxicity yet no improvement in chilled boar spermatozoa