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There are studies that have shown that stress affects a patients ability to achieve a euthyroid (normal thyroid gland function) state after the start of anti-thyroid medications

Zinman B., Gerich J., Buse J.B., Lewin A., Schwartz S., Raskin P., et al

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Another phase I trial (NCT00882674) in women with operable breast cancer and a phase II trial (NCT00796107) of R1507 in combination with letrozole in women with advanced breast tumors have finished, with results pending publication