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However, newer evidence suggests the relationship is more complex and that GIP activation in the context of GLP-1 activation might actually support fat burning

Meijer JL, Roderka MN, Chinburg EL, Renier TJ, McClure AC, Rothstein RI, et al

Glucagon-like peptide-1 evokes action potentials and increases cytosolic Ca 2+ in rat nodose ganglion neurons

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Supportive measures include electronic health record screening for food and nutrition security, curricular and accreditation interest in medical nutrition education, and expanded care pathways and reimbursement models [222]

A study by Mitchell et al used a surgically implanted intracranial pressure (ICP) monitor and showed reduction in ICP within minutes to hours after GLP-1 RA initiation long before weight loss would have occurred