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Stephens research group

By mimicking the GLP-1 hormone that is typically released post-meal, semaglutide enhances feelings of fullness and reduces the urge to eat excessively

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While earlier medications focused solely on the GLP-1 pathway, tirzepatides dual-action approach allows it to address metabolic health from two angles

Metabolic conditions that increase alpha-cell mass (9, 17, 44) also increase alpha-cell PC1/3 expression (13, 61) and GLP-1 production (41, 75, 86)