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After PSM, the number of participants in the SGLT2i group reduced from 992 to 933 and from 1822 to 933 in the GLP-1 RA group

The interest in this potential effect stems from the understanding that GLP-1 receptors are present in brain regions associated with reward processing and addictive behaviours

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placebo), while higher weekly doses (3.04.5 mg) achieved reductions of up to 1.51% at 36 weeks

Glucagon receptor activation was initially considered counterproductive for obesity treatment