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The expression of intestinal endocrine Lcells is regulated by several key receptors activated by short chain fatty acids (SCFAs), specific endogenous cannabinoids and bile acids, and the activation of these receptors increases the secretion of key intestinal peptides, such as GLP-1, GLP-2 and polypeptide YY (PYY) ( in vitro , leading to an increase in GLP-1 release (Petersen et al., 2014)

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Least-squares means two-tailed t -test P values were corrected for multiple testing using the BH method (adjusting for the numbers of treatment comparisons and time points)

Who Qualifies in Canada Eligibility depends on which brand (and which indication) is on the table: Ozempic / Rybelsus (on-label): adults with type 2 diabetes needing improved glycemic control, often as a second-line agent after metformin

Complete somatic genomics (DNA, RNA-seq and miRNA-seq) for all participants, with proteomics and PTMs for 162 participants, metabolomics and lipidomics for 97 participants and matched normal DNA for 161 participants were collected (Extended Data Fig

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