HPG Axis Suppression by Obesity Leptin resistance and hyperinsulinemia, both features of obesity, suppress GnRH pulsatility at the hypothalamus
Figure 5 Endocrine-related tumors, such as breast and prostate cancers, exhibit complex interactions within their tumor microenvironment (TME), where lipid metabolism plays a pivotal role (147)
Meg Tirrell 00:01:31 But last time we talked in the podcast
It's not dangerous, but it can: Add 13kg of scale weight (masking actual fat loss) Cause visible puffiness in legs or hands Be uncomfortable if severe What to do if you notice edema: Reduce KLOW dose by 50% and reassess after 2 weeks If on a daily frequency, drop to 3x/week If it persists, switch to pinning BPC-157 and GHK-Cu separately, leaving TB-500 out until the edema resolves Stay well-hydrated (counterintuitively, more water can help flush the retained fluid) Most people find edema resolves once the body adapts in weeks 24, or by reducing frequency
Compounded semaglutide is often more affordable but requires proper mixing
Your clinician sets the schedule, and the same NHS management guidance is used across services to keep it consistent
