Jacqueline Maya, M.D., from Massachusetts General Hospital-Mass General Brigham in Boston, and colleagues conducted a retrospective cohort study of 149,790 singleton pregnancies delivered between June 1, 2016, and March 31, 2025, to compare weight gain and pregnancy outcomes with and without exposure to GLP-1 RAs before or during early pregnancy
Together, these data suggest potentially distinct cellular/molecular effects of BPA depending on exposure age, concentration, and cell type
Of note, a significant decrease in total, LDL-cholesterol and in triglycerides has been revealed following CAB therapy in male hyperprolactinemic patients with concomitant hypogonadism, with no further improvement in lipid profile after 12 months of testosterone replacement therapy (52)
Mandrika and colleagues (Biochem Pharmacol, 2001, PMID 11239505) examined melanocortin peptides on NF-B DNA binding in RAW 264.7 macrophage-like cells and reported evidence for dual mechanisms of action, and Kannengiesser and colleagues (Inflamm Bowel Dis, 2008, PMID 18092346) reported effects in murine colitis models that were partly independent of MC1R
Mechanisms Methods 30 (6), 397406
GLP-1 therapy becomes more effective when combined with support that fosters positive behavior changes
