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Included patients had been enrolled in either one of two commercial insurance programs, one managed care program, or one Medicaid program for at least 9 months

Risks / unknowns: Lower efficacy of "natural" alternatives compared to clinical drugs

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Efficacy of invasive and non-invasive brain modulation interventions for addiction

A biomarker effect without a clinical one, as seen in EVOKE, is exactly the dissociation that should make researchers cautious about surrogate measures

252 However, a subsequent study was not able to confirm that liraglutide therapy improved psoriasis prognosis