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Early proof-of-concept and phase 2 studies suggested that tirzepatide can improve both markers of beta cell function and insulin sensitivity compared with selective GLP-1 RA therapy [9, 10]

GLP-1 medicationsincluding semaglutide (Ozempic, Wegovy), dulaglutide (Trulicity), liraglutide (Victoza, Saxenda), and exenatide formulationsmust typically be stored between 2C and 8C before opening

Losing a significant amount of weighttypically more than 10kgcan make other medications more effective

Any potential synergy remains theoretical and unproven in human studies

Another study found that people with opioid or alcohol use disorder who took GLP-1s had a 40% lower rate of opioid overdose and a 50% lower rate of alcohol intoxication than people who weren't on the medications

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